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KMID : 0370220040480020165
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Yakhak Hoeji
2004 Volume.48 No. 2 p.165 ~ p.170
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Effect of the Selaginella tamariscina Extract on Antioxidation and Inhibition of Matrix Metalloproteinase-1 in Human Skin Fibroblasts
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심관섭/Sim GS
김진화/박성민/이범천/윤여표/Yong He Zhang/표형배/Kim JH/Park SM/Lee BC/Yun YP/Zhang YH/Pyo HB
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Abstract
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The production of matrix metalloproteinases (MMPs) by the UV irradiated skin fibroblast and the degradation of extracellular matrix (ECM) by these enzymes is known as one of t he main reasons of photoaging. In this papers to inverttigate the relationship between aging and Selaginella tamariscina extract (STE), we investigated the effects of antioxidant and expression of UVA-induced MMP-1 in human dermal fibroblasts. STE was fecund to show scavenging activities of radicals and reactive owgen species (ROS) with the Icso values of 65.1 ㎍/ml against 1,1-diphenyl- 2-picrylhydrazyl(DPPH) radical and 40.9 ㎍/ml against superoxide radicals in the xanthine/xanthine oxidase system, respectively. UVA Induced MMP expression was reduced 75.5% by treatment with STE, and MMP-1 mRNA expression was reduced in a dose- dependent manner Therefore STE was able to significantly inhibition of MMP expression in protein and mRNA level. All these results suggested that STE may act as an anti- aging agent by antioxidation and reducing UVA-induced MMP-1 production.
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